Doctors here say, calcium, vitamin D, the forgotten part of the Prevention of Disease
Half of women over 50 years in the U.S. and one in four men will have osteoporosis-related fractures in the rest of the service, said that National Endowment for osteoporosis. This disease is characterized by reduced bone mass and structural bone leading to bone fragility and increased susceptibility of fractures, is a serious threat to the health of 44 million Americans, or more than half of all people over 50 years, the foundation says. In Spokane, the level of hip fracture "is much higher than they should be", and osteoporosis often plays an important role in these fractures, said Dr. Lynn Kohlmeier, Centers Spokane osteoporosis. This year, Spokane, the area suffer osteoporosis will participate in studies of two new drugs that have not yet received approval from the U.S. Food and Drug Administration. The study is expected to begin within a few months, about 20 patients here take the drug, called denosumab, monoclonal antibodies, which is administered twice a year in osteoporosis suffer increasing bone mineral density, Kohlmeier said. Monoclonal antibodies are clones of a single cell parents. The study will compare with other denosumab osteoporosis drug called Fosamax, which has been on the market for some time. So far, denosumab was "excellent preliminary data," said Kohlmeier, who expects that it can be approved within the next two years. In addition, earlier this year, the Centers Spokane Osteoporosis is planning to register about 20 patients in the trial for Reclast, which is part of a class of drugs called bisphosphonates and is introduced during the 15-minute intravenous infusion once a year. Reclast is the lower dose version of another drug called Zometa, which was used to treat cancer that has spread to bone. In studies so far, been Reclast "showed fantastic reduction in hip fracture and spine," she says. Reclast could be approved next year, she says. Meanwhile, the new "designer estrogen" called bazedoxifene, which is part of a class of drugs called selective estrogen receptor modulator (SERMs), may become available for several years, says Dr. Jill Gronholz, bone density in North Idaho, is located in Coeur d'Alene. Earlier Gronholz enrolled 15 patients in a multicenter study of this drug in a much larger trial. The results of this trial were sent to the FDA, but the drug was not approved yet, she says. In addition, the drug strontium ranelate, which was approved in Europe but not in the U.S., has been shown to stop the destruction of bone and stimulate new bone growth, says Dr. Fred Viren, Spokane Osteoporosis Detection and Treatment Center here. Viren expects that it will be approved in the U.S. eventually. In the last decade, drug manufacturers have introduced several new drugs osteoporosis. Fosamax and Actonel, bisphophonates, taken orally once a week, have been shown to reduce hip and / or fractures of the spine in addition to fractures of the spine, Kohlmeier said. Third bisphosphonates, bonds, can be taken orally once a month, and recently became available through intravenous infusion, every three months, she says. In rare cases, people receiving intravenous bisphosphonates for cancer treatment have developed osteonecrosis of the jaw, which includes serious jaw bone destruction, says the website of American Dental Association. In more rare cases, patients taking oral bisphosphonates developed osteonecrosis. In most cases of osteonecrosis have been diagnosed after dental procedures such as tooth extraction, the site says. Viren says potential risks is important to consider when making almost any medication, including bisphosphonates, but the benefits of bisphosphonates for the treatment of osteoporosis patients far outweigh these risks. Another drug, Evista, is a SERM, which helps build bones and has been shown to reduce the risk of developing breast cancer by about 50 percent of women who are at high risk of developing breast cancer, but not approved by the FDA for breast cancer contain none less, Kohlmeier said. SERMs block the action of estrogen in breast and other tissues, taking estrogen receptors in cells. Another drug, called Forteo, is what is known as parathyroid hormone, which stimulates the formation of new bone, she says. Forteo is introduced into the body daily, and has been shown to reduce and without spinal fractures and spine. "The fact that we can now understand that we can stop excessive bone destruction using drugs and drugs that stimulate the formation of new bone tissue is a major achievement," says Viren. "More attention was paid to osteoporosis, but not enough."
Federal Government has caused a huge impact on osteoporosis prevention and treatment, when it passed a law two years ago, leading to a decrease in the number of tests performed to diagnose diseases, Gronholz says. This decision was made three years after President Bush declared the years 2002-2011 National Bone and Joint Decade, she says. Under the law of deficit reduction in 2005, Medicare reimbursement bone density testing will be reduced by 40 percent starting this month, Gronholz says. A 70-percent reduction by 2010 has also been proposed.
Kohlmeier said she was also concerned about the implications of new legislation regarding detection and treatment of osteoporosis. Spokane Osteoporosis Centers offers bone density testing at three sites near Spokane. Free bone density tests conducted on five of ultrasound offered in community centers, educational screening at Deaconess Medical Center, Valley Hospital & Medical Center, and Sacred Heart Medical Center, she says. Free five bone density tests also will be offered in the triathlon, which will maintain awareness of osteoporosis in medical lake this summer. In addition to drug therapy and bone density selection, weight-bearing exercise, a diet rich in calcium and vitamin D are important factors in combating and preventing osteoporosis, Viren says. U.S. Public Health recommends 15 to 20 minutes of exercise five times a week to maintain good bone strength, and adequate calcium intake from 1200 to 1500 milligrams a day, he says. Viren says two-thirds of Americans have a deficiency of vitamin D, and the federal government recommends consumption of vitamin D from 400 to 600 units per day. Deficiency is more common in people of the Northern U.S. states, as well as direct sunlight is a source of vitamins, he says. "The most important step forward in recent years, understanding deficiency of vitamin D," says Viren. "If adequate doses as calcium, we can prevent this disease."
At the end of last month, researchers published the results of large-scale study in Britain found that the popular heartburn drugs like Nexium, Prevacid, Prilosec for a year or more can significantly increase the risk that people over 50 will suffer a broken hip . Researchers suspect that the drugs that are part of a class of drugs called proton pump inhibitors, make it more difficult for the body to absorb calcium, reducing acid in the stomach. The study found less risk of hip fractures for another class of drugs called blockers, H2, including Tagamet Pepcid. Kohlmeier said that a healthy intake of vitamin D and calcium can offset the potential decrease in the absorption of proton pump inhibitors. She adds, however, that there may be other lasix 16 mg ways, such drugs affect fracture risk. Gronholz said that in addition to dietary supplements and exercise, women may also prevent fractures caused by falls to wearing hip protectors. People should also refrain from known risk factors such as malnutrition, smoking and excessive alcohol consumption, she says. Contact Emily Brandlera at (509) 344-1265 or e-mail emilyb @ spokanejournal. com. .
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